Update: Some quick notes…
Here are some stills from the Simpsons episode Stark Raving Dad, which pays homage to One Flew Over the Cuckoo’s Nest (and one still that references The Silence of the Lambs, which is alluded to in a number of episodes):
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There's other references to this movie in an episode where bart works at the retirement home, he takes the old people on a boat trip and in the end an indian breaks the window and escapes. And returns and breaks another window to get his hat.
Isn't the first scene a reference to Silence of the Lambs?
There was also the one where (I forget the circumstances leading up to this moment... but) Homer was in a sick bed, and Barney holds a pillow over Homer's face, like Chief did to Jack in Cuckoo's Nest. He holds it there for like 3 seconds and doesn't kill Homer (obviously...) Then, Barney hoists a modern water fountain, hurls it through the window, and runs off into the horizon. It was one of the funniest Simpsons moments I've ever seen.
The episode where Barney throws the water fountain is an April Fools episode where they showed clips from previous episodes. The situation that you're talking about, Pete, is when Moe offers Homer a Duff and Homer cowers in fear. Barney exclaims, "I can't stand to see him like this!" and then smothers Homer. Great episode.
Homer's Triple Bypass, an episode in which Homer finds himself laying the hospital, waiting for bypass surgery. In one scene, Barney smoothers Homer with a pillow, wrenches free a hospital sink, throws it out the window, and runs off while eerie saw music plays in the background. One of the most blatant, and funniest, references to Cuckoo's Nest.